MovDisordV3, Main, Exploration, bibRecord, 001B82

Mild parkinsonian signs are associated with increased risk of dementia in a prospective, population‐based study of elders

Identifieur interne : 001B82 ( Main/Exploration ); précédent : 001B81; suivant : 001B83

Mild parkinsonian signs are associated with increased risk of dementia in a prospective, population‐based study of elders

Auteurs : Elan D. Louis [États-Unis] ; Ming X. Tang [États-Unis] ; Nicole Schupf [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2010-01-30.

RBID : ISTEX:8D1A7D2FBC959D7365D0C765854C30EFF04D0886

Descripteurs français

Pascal (Inist)
- Démence d'Alzheimer, Epidémiologie, Facteur risque, Maladie de Parkinson, Pathologie du système nerveux, Personne âgée, Prospective, Signe.
Wicri :
- topic : Personne âgée, Prospective.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Aging (psychology), Alzheimer disease, Alzheimer's disease, Dementia (diagnosis), Dementia (epidemiology), Dementia (etiology), Elderly, Epidemiology, Female, Follow-Up Studies, Humans, Incidence, Male, Muscle Rigidity (physiopathology), Nervous system diseases, Neuropsychological Tests, New York City (epidemiology), Parkinson Disease (complications), Parkinson Disease (epidemiology), Parkinson Disease (physiopathology), Parkinson disease, Population Groups, Proportional Hazards Models, Prospective, Prospective Studies, Psychiatric Status Rating Scales, Risk Factors, Risk factor, Severity of Illness Index, Sign, Tremor (physiopathology), elderly, epidemiology, incident dementia, mild parkinsonian signs, population.
MESH :
- geographic , epidemiology : New York City.
- complications : Parkinson Disease.
- diagnosis : Dementia.
- epidemiology : Dementia, Parkinson Disease.
- etiology : Dementia.
- physiopathology : Muscle Rigidity, Parkinson Disease, Tremor.
- psychology : Aging.
- Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Incidence, Male, Neuropsychological Tests, Population Groups, Proportional Hazards Models, Prospective Studies, Psychiatric Status Rating Scales, Risk Factors, Severity of Illness Index.

Abstract

There is some evidence that mild parkinsonian signs (MPSs) are associated with increased risk of dementia, suggesting that MPS could be an early biomarker for dementia. Our aims, in a new cohort, were to determine whether (1) baseline MPS are a predictor of incident dementia and (2) there is an interaction between MPS and other baseline risk factors for dementia (i.e., the presence of both together greatly elevates the risk of dementia) was the objective. In a prospective, longitudinal study of community‐dwelling elders in northern Manhattan, NY, Parkinsonian signs were rated with an abbreviated Unified Parkinson's Disease Rating Scale. Risk of incident dementia was assessed using Cox proportional hazards models. There were 1,851 participants (mean follow‐up = 3.7 years). Participants with baseline MPS were twice as likely to develop dementia as participants without MPS: 16.3% versus 7.7%, unadjusted hazards ratio (HR) = 2.24 (P< 0.001), adjusted HR = 1.98 (P < 0.001). MPS were divided into three subtypes: adjusted HRaxial dysfunction = 2.45 (P < 0.001), adjusted HRtremor = 2.38 (P = 0.006), and adjusted HRrigidity = 1.16 (P = 0.58). When MPS were treated as a continuous variable, the adjusted HR = 1.15 (P = 0.001). There were no interactions between MPS and other baseline risk factors for dementia, including gender, education, race, family history of dementia, stroke, and apolipoprotein E‐e4. Baseline MPS seems to be a predictor of incident dementia. These motor signs might, therefore, serve as a useful biomarker for emerging dementia. © 2010 Movement Disorder Society

Url:

DOI: 10.1002/mds.22943

Affiliations:

Le document en format XML

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<term>Aged, 80 and over</term>
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<term>Alzheimer disease</term>
<term>Alzheimer's disease</term>
<term>Dementia (diagnosis)</term>
<term>Dementia (epidemiology)</term>
<term>Dementia (etiology)</term>
<term>Elderly</term>
<term>Epidemiology</term>
<term>Female</term>
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<term>Incidence</term>
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<term>Muscle Rigidity (physiopathology)</term>
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<term>Neuropsychological Tests</term>
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<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (physiopathology)</term>
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<term>Prospective Studies</term>
<term>Psychiatric Status Rating Scales</term>
<term>Risk Factors</term>
<term>Risk factor</term>
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<term>Sign</term>
<term>Tremor (physiopathology)</term>
<term>elderly</term>
<term>epidemiology</term>
<term>incident dementia</term>
<term>mild parkinsonian signs</term>
<term>population</term>
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<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Dementia</term>
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<term>Incidence</term>
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<front><div type="abstract" xml:lang="en">There is some evidence that mild parkinsonian signs (MPSs) are associated with increased risk of dementia, suggesting that MPS could be an early biomarker for dementia. Our aims, in a new cohort, were to determine whether (1) baseline MPS are a predictor of incident dementia and (2) there is an interaction between MPS and other baseline risk factors for dementia (i.e., the presence of both together greatly elevates the risk of dementia) was the objective. In a prospective, longitudinal study of community‐dwelling elders in northern Manhattan, NY, Parkinsonian signs were rated with an abbreviated Unified Parkinson's Disease Rating Scale. Risk of incident dementia was assessed using Cox proportional hazards models. There were 1,851 participants (mean follow‐up = 3.7 years). Participants with baseline MPS were twice as likely to develop dementia as participants without MPS: 16.3% versus 7.7%, unadjusted hazards ratio (HR) = 2.24 (P< 0.001), adjusted HR = 1.98 (P < 0.001). MPS were divided into three subtypes: adjusted HRaxial dysfunction = 2.45 (P < 0.001), adjusted HRtremor = 2.38 (P = 0.006), and adjusted HRrigidity = 1.16 (P = 0.58). When MPS were treated as a continuous variable, the adjusted HR = 1.15 (P = 0.001). There were no interactions between MPS and other baseline risk factors for dementia, including gender, education, race, family history of dementia, stroke, and apolipoprotein E‐e4. Baseline MPS seems to be a predictor of incident dementia. These motor signs might, therefore, serve as a useful biomarker for emerging dementia. © 2010 Movement Disorder Society</div>
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Movement Disorders (revue)

Mild parkinsonian signs are associated with increased risk of dementia in a prospective, population‐based study of elders

Mild parkinsonian signs are associated with increased risk of dementia in a prospective, population‐based study of elders

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.